I have a love/hate relationship with FLOSS Weekly. On one hand they provide an excellent podcast that provides information on a lot of FLOSS software but on the other they create a bunch of potential experiments for me. :-)

I just listened to the interview they did with Matt Ranney about Node.js. Matt provided a really excellent rundown of why someone would want to try using Node.js and it's made me want to try it. The thing I find most interesting about the Node.js platform is that it's just running Javascript which means you don't have to learn another language (if you already know JS). They also claim that it has excellent performance due to the event driven nature of the platform.

I would highly recommend watching/listening to the podcast for more information:

http://twit.tv/show/floss-weekly/237